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Barry Humphries: Comic battled inoperable EMPD cancer for years

Barry Humphries: Comic battled inoperable EMPD cancer for years

Barry Humphries fought a secret battle with inoperable cancer for years before his death last week.

The Australian actor and comic, known for his alter ego Dame Edna Everage, died aged 89 on April 22 following complications from a recent hip replacement surgery.

“Close family sources” confirmed to the The Saturday Telegraph he had been diagnosed with Extramammary Paget’s disease, a rare form of skin cancer, in 2021 after noticing “something unusual” on one of his testicles when he was in the shower.

EMPD Interdisciplinary Management Using MMS-CK7 Immunostains

EMPD Interdisciplinary Management Using MMS-CK7 Immunostains

For a study, researchers sought to assess the local recurrence rates and patient-reported outcomes when extramammary Paget’s disease (EMPD) is treated with Mohs micrographic surgery with cytokeratin-7 immunostains (MMS-CK7).

In-depth internal malignancy screening, low local recurrence rates, and high patient satisfaction were all characteristics of interdisciplinary teams that successfully treat EMPD.

After noticing “something weird” in the shower, Barry Humphries (AKA Dame Edna Everage), was diagnosed with extramammary Paget’s disease (EMPD).

After noticing “something weird” in the shower, Barry Humphries (AKA Dame Edna Everage), was diagnosed with extramammary Paget’s disease (EMPD).

After noticing “something weird” in the shower, Barry Humphries was diagnosed with a rare malignancy.

After detecting something weird with his testicles in the shower, BARRY HUMPHRIES realized he had a rare form of skin cancer.

Barry Humphries, better known as Dame Edna Everage, has revealed that he was diagnosed with Paget’s Disease, a type of skin cancer. Following the finding, the Australian actor revealed that he had surgery.

Key signaling pathway in the pathogenesis of Paget's disease identified

Key signaling pathway in the pathogenesis of Paget's disease identified

Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of poorly understood malignant skin cancers collectively known as Paget's disease. The team identified new biomarker genes that highly correlate with Paget's disease. The group then used a Food and Drug Administration (FDA) approved drug to target one of the newly identified molecular features of Paget's disease, leading to prominently improved clinical symptoms in a small cohort of Chinese patients. Their results have been published online in Cell Research.

胯下紅疹似濕疹拖一年求醫 50歲男患癌延醫脊椎被侵蝕

胯下紅疹似濕疹拖一年求醫 50歲男患癌延醫脊椎被侵蝕

台灣一名壯年男子出現胯下痕癢,但由於患處位於生殖器附近,男子怕尷尬不敢求醫,1年後做檢查始發現患上皮膚癌,而男子因延誤治療導致癌細胞擴散,3分之1的脊椎骨被侵蝕。有臨床腫瘤科專科醫生表示,此皮膚癌病徵與濕疹相似,難靠肉眼分辨,若搽類固醇藥膏仍未有改善,宜盡快做檢查。

胯下出疹羞求醫 一年後揭患癌

據台媒報道,當地一名年約50歲男子運動後出現胯下痕癢、破皮、紅疹等症狀,但由於患處位於生殖器附近,事主因不好意思求醫遂自行擦藥膏,1年後情況未見好轉,到醫院檢查始發現患上乳房外柏哲德氏病(Extramammary Paget's Disease),但因延誤治療,汗腺細胞已突變為癌細胞,並順淋巴擴散附在器官與骨頭上,影像檢查發現有3分1脊椎骨都被侵蝕。

症狀與濕疹相似

主治的皮膚科醫生江建平表示,乳房外柏哲德氏病屬皮膚癌的一種,可分為原發型及繼發型,前者源自皮膚大汗腺細胞病變;後者則是因病患患有其他器官癌症之皮膚轉移。疾病好發於汗腺較發達部位,如腋下、胯下、生殖器肛門口周圍皮膚,外觀似濕疹、股癬,初期會出現局部搔癢、疼痛症狀,之後患處會漸漸擴大,甚至出現隆起、組織液滲出、潰瘍等狀況。若患者延誤治療,可導致淋巴結或遠端器官轉移。

胯下好癢可以到藥房買成藥嗎?醫生提醒:小心擦出問題!

胯下好癢可以到藥房買成藥嗎?醫生提醒:小心擦出問題!

臺北市立聯合醫院和平婦幼院區皮膚科醫師李孟穗表示,胯下癢是皮膚科門診中常見的求診症狀,常見的發作部位包括大腿內側或股溝處,或是女性私密處、男性陰囊等。

「胯下癢發作時會搔癢無比,讓人坐立難安,不抓難受,抓了又不雅觀,但由於病灶在隱私部位,不少病患不願意就醫,而選擇自行到藥局購買外用藥膏來塗抹,結果常因擦了不適當的藥膏,造成病情惡化時,才向醫師求助,」李孟穗指出。

李孟穗表示,很多皮膚病都會出現胯下癢的情形,可能是黴菌或細菌、病原蟲感染造成的,也可能因皮膚受到持續摩擦刺激,再加上衣褲包覆悶熱導致,包括:股癬、念珠菌感染、紅癬、疥瘡、陰蝨、濕疹、對磨疹或少見的乳房外柏杰氏病(Extramammary Paget’s disease, EMPD)等疾病。

Jangan Anggap Remeh Gatal-Gatal Di 5 Area Vital Laki-Laki Ini

Jangan Anggap Remeh Gatal-Gatal Di 5 Area Vital Laki-Laki Ini

Skrotum atau area kulit testis, atau lebih awam dikenal dengan istilah area buah zakar, kerap juga menjadi sasaran keluhan gatal pada area alat vital pria. Berikut beberapa pencetus keluhan gatal pada area buah zakar:

- Eksim: merupakan suatu penyakit kulit kronis yang ditandai dengan gatal, peradangan dan kemerahan pada kulit

- Extramammary Paget’s disease: merupakan suatu keganasan kulit pada kulit skrotum yang terlihat serupa dengan eksim.

Penting diketahui, karena kondisi gatal yang muncul pada area skrotum seringkali kronis (menahun) jangan menunda untuk melakukan pemeriksaan untuk pengobatan.

Jangan Sepelekan Gatal di Sekitar Kemaluan Pria!

Jangan Sepelekan Gatal di Sekitar Kemaluan Pria!

Skrotum atau area kulit testis, atau lebih awam dikenal dengan istilah area buah zakar, kerap juga menjadi sasaran keluhan gatal pada area alat vital pria. Berikut beberapa pencetus keluhan gatal pada area buah zakar:

  • Eksim: merupakan suatu penyakit kulit kronis yang ditandai dengan gatal, peradangan dan kemerahan pada kulit

  • Extramammary Paget’s disease: merupakan suatu keganasan kulit pada kulit skrotum yang terlihat serupa dengan eksim.

Penting diketahui, karena kondisi gatal yang muncul pada area skrotum seringkali kronis (menahun) jangan menunda untuk melakukan pemeriksaan untuk pengobatan.

MSK Researchers Develop Targeted Test for Mutations in Both Rare and Common Cancers

MSK Researchers Develop Targeted Test for Mutations in Both Rare and Common Cancers

Building on our rich history of innovation, genome scientists, bioinformaticians and molecular pathologists at Memorial Sloan Kettering Cancer Center have developed a targeted tumor sequencing test, MSK-IMPACT™ (Integrated Mutation Profiling of Actionable Cancer Targets), to detect gene mutations and other critical genetic aberrations in both rare and common cancers. Until now, genomic testing of tumors has been routine practice only for patients with certain solid tumors, such as melanoma, lung, and colon cancer. MSK-IMPACT™ is much more inclusive and can be used on any solid tumor regardless of its origin, potentially offering better treatment options for thousands of patients in the form of precision oncology